Seroatlas · Human Serome Atlas

AP3S1

AP-3 complex subunit sigma-1

Also known as: AP3S1_HUMAN, CLAPS3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92572
Gene: AP3S1
Ensembl: ENSG00000177879
Chromosome: 5
Canonical length: 193 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a subunit of the AP3 adaptor complex. This complex functions in the formation of subcellular vesicles budded from the Golgi body. Several related pseudogenes of this gene have been found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q92572|AP3S1
     1  MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD
    61  NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL
   121  AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS EAGLAGAPAR AVSAVKNMNL PEIPRNINIG
   181  DISIKVPNLP SFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AP3S1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 126 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 126 nTPM
blood vessel: 113 nTPM
epididymis: 107 nTPM
hippocampal formation: 86 nTPM
cerebral cortex: 83 nTPM
ovary: 83 nTPM

Single-cell type

esophageal apical cells: 514 nCPM
extravillous trophoblasts: 404 nCPM
neutrophil progenitors: 339 nCPM
late spermatids: 324 nCPM
enterocytes: 320 nCPM
epididymal principal cells: 213 nCPM

Immune cell

eosinophil: 175 nTPM
neutrophil: 111 nTPM
plasmacytoid DC: 95 nTPM
basophil: 82 nTPM
intermediate monocyte: 79 nTPM
non-classical monocyte: 76 nTPM

Brain region

pons: 44 nTPM
hippocampal formation: 41 nTPM
cerebral cortex: 40 nTPM
hypothalamus: 40 nTPM
midbrain: 40 nTPM
medulla oblongata: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AP3S1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AP3S1 as an antibody target. Whether an autoantibody or antibody against AP3S1 could matter depends on whether native AP3S1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AP3S1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AP3S1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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