Seroatlas · Human Serome Atlas

AP3S2

AP-3 complex subunit sigma-2

Also known as: AP3S2_HUMAN, sigma3b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59780
Gene: AP3S2
Ensembl: ENSG00000157823
Chromosome: 15
Canonical length: 193 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of AP-3 adaptor complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>P59780|AP3S2
     1  MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL EGGSLIGGSD
    61  YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHMDKVHYIL
   121  QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS EGGLSAAPAR AVSAVKNINL PEIPRNINIG
   181  DLNIKVPNLS QFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AP3S2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

tongue: 42 nTPM
skeletal muscle: 42 nTPM
retina: 41 nTPM
liver: 38 nTPM
kidney: 34 nTPM
parathyroid gland: 31 nTPM

Single-cell type

choroid plexus epithelial cells: 120 nCPM
microglia: 78 nCPM
oligodendrocytes: 68 nCPM
bergmann glia: 57 nCPM
oligodendrocyte progenitor cells: 56 nCPM
ependymal cells: 54 nCPM

Immune cell

non-classical monocyte: 20 nTPM
classical monocyte: 17 nTPM
neutrophil: 16 nTPM
intermediate monocyte: 16 nTPM
myeloid DC: 12 nTPM
total PBMC: 11 nTPM

Brain region

midbrain: 37 nTPM
pons: 36 nTPM
hypothalamus: 33 nTPM
thalamus: 32 nTPM
white matter: 31 nTPM
medulla oblongata: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AP3S2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AGAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AP3S2 as an antibody target. Whether an autoantibody or antibody against AP3S2 could matter depends on whether native AP3S2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AP3S2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AP3S2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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