Seroatlas · Human Serome Atlas

TMEM132B

Transmembrane protein 132B

Also known as: KIAA1786, KIAA1906, T132B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14DG7
Gene: TMEM132B
Ensembl: ENSG00000139364
Chromosome: 12
Canonical length: 1078 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1078 residues, UniProt reviewed canonical sequence.

>Q14DG7|TMEM132B
     1  MFGAASRMDT TAVCTGGVTE SRGIVDSLQK FSSLPAYLPT NLHISNAEES FFLKEANQDL
    61  TRNSSLQARV EPFFIYRART PPIINASYGP FSVEKIIPQE LLLTSTAFGN MDKFPFNWKL
   121  KSHILDSSIY SNRPKVQTLF YVTGMGWDDS DLTEDLPCVK MFAFPEAREV AASCRLQGAP
   181  GLCVAELELL PEWFSSGLDL EPEEEIPALL GGTTMELFFT LYPADKAGQC PLEEEGKWEN
   241  NIHSGLESPQ QAFPARERIG SVVVYPTQDD LKWSLVSLDE NVVISVPLNL VREGDTATFL
   301  VSLTSSSVAD QFTLRIKAAA GVKITAVRVS SEDQWAVQEE IDNGSTQTSA TLTCMGHRPD
   361  TQSRVNGSFY EILQVDFGID NSSDLAGAQQ ITWQVEYPIE DSMSELVVSE IFVSQTTFVG
   421  IVPLAMDTEV LNTAILTGKP VSVPVKVVGV QEDGSVVDVS ESVECKSADE DVIKVSNNCD
   481  SIFVNGKEMK SKVDTIVNFT HQHFTSQFEV TVWAPRLPLQ IEISDTELSQ IKGWRIPVAA
   541  NRRPTRESDD EDDEEKKGRG CSLQYQHATV RVLTQFVAES PDLGQLTYML GPDWQFDITD
   601  LVTEFMKVEE PKIAQLQDGR TLAGREPGIT TVQVLSPLSD SILAEKTVIV LDDRVTIAEL
   661  GVQLVAGMSL SLQPHRADKR AIVSTAAALD VLQSPQQEAI VSSWILFSDG SVTPLDIYDP
   721  KDYSVTVSSL DEMVVSVQAN LESKWPIVVA EGEGQGPLIK LEMMISEPCQ KTKRKSVLAV
   781  GKGNVKVKFE PSSDEHQGGS NDIEGINREY KDHLSNSIER EGNQERAVQE WFHRGTPVGQ
   841  EESTNKSTTP QSPMEGKNKL LKSGGPDAFT SFPTQGKSPD PNNPSDLTVT SRGLTDLEIG
   901  MYALLCVFCL AILVFLINCV AFAWKYRHKR FAVSEQGNIP HSHDWVWLGN EVELLENPVD
   961  ITLPSEECTT MIDRGLQFEE RNFLLNGSSQ KTFHSQLLRP SDYVYEKEIK NEPMNSSGPK
  1021  RKRVKFTSYT TILPEDGGPY TNSILFDSDD NIKWVCQDMG LGDSQDFRDY MESLQDQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM132B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 13 nTPM
basal ganglia: 9.4 nTPM
amygdala: 7.9 nTPM
hippocampal formation: 6.8 nTPM
hypothalamus: 3.7 nTPM
midbrain: 3.1 nTPM

Single-cell type

brain inhibitory neurons: 429 nCPM
oligodendrocyte progenitor cells: 391 nCPM
brain excitatory neurons: 368 nCPM
other brain neurons: 265 nCPM
astrocytes: 249 nCPM
oligodendrocytes: 246 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 42 nTPM
basal ganglia: 29 nTPM
hippocampal formation: 27 nTPM
white matter: 27 nTPM
amygdala: 23 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 1.47
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM132B as an antibody target. Whether an autoantibody or antibody against TMEM132B could matter depends on whether native TMEM132B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM132B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM132B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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