Seroatlas · Human Serome Atlas

TMEM132E

Transmembrane protein 132E

Also known as: DFNB99, T132E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IEE7
Gene: TMEM132E
Ensembl: ENSG00000181291
Chromosome: 17
Canonical length: 1074 aa
Protein class: Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Nuclear bodies,Golgi apparatus,Cytosol

OverviewNCBI Gene

Involved in posterior lateral line neuromast hair cell development. Predicted to be located in cell body. Implicated in autosomal recessive nonsyndromic deafness 99. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1074 residues, UniProt reviewed canonical sequence.

>Q6IEE7|TMEM132E
     1  MAPGMSGRGG AALLCLSALL AHASGRSHPA SPSPPGPQAS PVLPVSYRLS HTRLAFFLRE
    61  ARPPSPAVAN SSLQRSEPFV VFQTKELPVL NVSLGPFSTS QVVARELLQP SSTLDIPERL
   121  TVNWKVRAFI VRSHVPASQP VVQVLFYVAG RDWDDFGVTE RLPCVRLHAF RDAREVKSSC
   181  RLSGGLATCL VRAELPLAWF GPPAPAAPPT ARRKSPDGLE PEATGESQQA ELYYTLHAPD
   241  ASGGCGGSRR GAGPGVGARA ESPTQHPLLR IGSISLFRPP PRRTLQEHRL DSNLMIRLPD
   301  RPLKPGEVLS ILLYLAPNSS SPSSPSVEHF TLRVKAKKGV TLLGTKSRSG QWHVTSELLT
   361  GAKHSTATVD VAWAQSTPLP PREGQGPLEI LQLDFEMENF TSQSVKRRIM WHIDYRGHGA
   421  LPDLERAVTE LTVIQRDVQA ILPLAMDTEI INTAILTGRT VAIPVKVIAI EVNGLVLDIS
   481  ALVECESDNE DIIKVSSSCD YVFVSGKESR GSMNARVTFR YDVLNAPLEM TVWVPKLPLH
   541  IELSDARLSQ VKGWRVPILP DRRSVRESED EDEEEEERRQ SASRGCTLQY QHATLQVFTQ
   601  FHTTSSEGTD QVVTMLGPDW LVEVTDLVSD FMRVGDPRVA HMVDSSTLAG LEPGTTPFKV
   661  VSPLTEAVLG ETLLTVTEEK VSITQLQAQV VASLALSLRP SPGSSHTILA TTAAQQTLSF
   721  LKQEALLSLW LSYSDGTTAP LSLYSPRDYG LLVSSLDEHV ATVTQDRAFP LVVAEAEGSG
   781  ELLRAELTIA ESCQKTKRKS VLATTPVGLR VHFGRDEEDP TYDYPGPSQP GPGGGEDEAR
   841  GAGPPGSALP APEAPGPGTA SPVVPPTEDF LPLPTGFLQV PRGLTDLEIG MYALLGVFCL
   901  AILVFLINCI VFVLRYRHKR IPPEGQTSMD HSHHWVFLGN GQPLRVQGEL SPPAGNPLET
   961  VPAFCHGDHH SSGSSQTSVQ SQVHGRGDGS SGGSARDQAE DPASSPTSKR KRVKFTTFTT
  1021  LPSEELAYDS VPAGEEDEEE EEDLGWGCPD VAGPTRPTAP PDLHNYMRRI KEIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM132E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 13 nTPM
cerebral cortex: 4 nTPM
hypothalamus: 3.4 nTPM
spinal cord: 3.2 nTPM
amygdala: 2.8 nTPM
kidney: 2.7 nTPM

Single-cell type

retinal amacrine cells: 22 nCPM
oligodendrocyte progenitor cells: 18 nCPM
other brain neurons: 17 nCPM
proximal tubule cells: 12 nCPM
kupffer cells: 11 nCPM
late spermatids: 11 nCPM

Immune cell

naive CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 40 nTPM
white matter: 25 nTPM
spinal cord: 21 nTPM
pons: 20 nTPM
cerebral cortex: 20 nTPM
thalamus: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM132E.

Disease | AllUniProt

Conditions TMEM132E is implicated in, by any mechanism.

Deafness, autosomal recessive, 99 (DFNB99) MIM:618481

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 364 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 1.34
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

posterior lateral line neuromast hair cell development

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM132E as an antibody target. Whether an autoantibody or antibody against TMEM132E could matter depends on whether native TMEM132E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM132E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM132E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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