Seroatlas · Human Serome Atlas

TMEM132C

Transmembrane protein 132C

Also known as: DKFZp761O2018, PPP1R152, T132C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3T6
Gene: TMEM132C
Ensembl: ENSG00000181234
Chromosome: 12
Canonical length: 1108 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1108 residues, UniProt reviewed canonical sequence.

>Q8N3T6|TMEM132C
     1  MRSEGAAPGP AAPLCGALSL LLGALLGKVI EGHGVTDNIQ RFSSLPPYLP VSYHILRAET
    61  SFFLKEANQD LLRNSSLQAR VESFFTYKTR QPPVLNASYG PFSVEKVVPL DLMLTSNFLG
   121  PTNKFSFDWK LKAHILRDKV YLSRPKVQVL FHIMGRDWDD HGAGEKLPCL RVFAFRETRE
   181  VRGSCRLKGD LGLCVAELEL LSSWFSAPTV GAGRKKSMDQ PEGTPVELYY TVHPGNERGD
   241  CAGGDFRKGN AIRPGKDGLE ETTSHLQRIG TVGLYRAQDS AQLSELRLDG NVVIWLPSRP
   301  VKQGEVVTAY VTISSNSSVD LFILRAKVKK GVNILSAQTR EPRQWGVKQE VGSGGKHVTA
   361  TVACQRLGPS PRNRSSSLFN EVVQMNFEIA SFSSLSGTQP ITWQVEYPRK GTTDIAVSEI
   421  FVSQKDLVGI VPLAMDTEIL NTAVLTGKTV AMPIKVVSVE ENSAVMDISE SVECKSTDED
   481  VIKVSERCDY IFVNGKEIKG KMDAVVNFTY QYLSAPLCVT VWVPRLPLQI EVSDTELSQI
   541  KGWRVPIVTN KRPTRESEDE DEEERRGRGC ALQYQHATVR VLTQFVSEGA GPWGQPNYLL
   601  SPNWQFDITH LVADFMKLEE PHVATLQDSR VLVGREVGMT TIQVLSPLSD SILAEKTITV
   661  LDDKVSVTDL AIQLVAGLSV ALYPNAENSK AVTAVVTAEE VLRTPKQEAV FSTWLQFSDG
   721  SVTPLDIYDT KDFSLAATSQ DEAVVSVPQP RSPRWPVVVA EGEGQGPLIR VDMTIAEACQ
   781  KSKRKSILAV GVGNVRVKFG QNDADSSPGG DYEEDEIKNH ASDRRQKGQH HERTGQDGHL
   841  YGSSPVEREE GALRRATTTA RSLLDNKVVK NSRADGGRLA GEGQLQNIPI DFTNFPAHVD
   901  LPKAGSGLEE NDLVQTPRGL SDLEIGMYAL LGVFCLAILV FLINCATFAL KYRHKQVPLE
   961  GQASMTHSHD WVWLGNEAEL LESMGDAPPP QDEHTTIIDR GPGACEESNH LLLNGGSHKH
  1021  VQSQIHRSAD SGGRQGREQK QDPLHSPTSK RKKVKFTTFT TIPPDDSCPT VNSIVSSNDE
  1081  DIKWVCQDVA VGAPKELRNY LEKLKDKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM132C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 29 nTPM
cervix: 15 nTPM
choroid plexus: 15 nTPM
breast: 13 nTPM
fallopian tube: 11 nTPM
basal ganglia: 8.6 nTPM

Single-cell type

adipocytes: 997 nCPM
oligodendrocyte progenitor cells: 806 nCPM
choroid plexus epithelial cells: 763 nCPM
endometrial stromal cells: 362 nCPM
retinal bipolar cells: 339 nCPM
cone photoreceptor cells: 197 nCPM

Immune cell

gdT-cell: 1.8 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 29 nTPM
midbrain: 27 nTPM
thalamus: 17 nTPM
medulla oblongata: 16 nTPM
pons: 15 nTPM
amygdala: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.64
gnomAD missense Z: 1.83

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM132C as an antibody target. Whether an autoantibody or antibody against TMEM132C could matter depends on whether native TMEM132C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM132C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM132C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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