Rec (regulator of expression encoded by corf) of HERV-K-113

Definition

REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homologue of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts PMID:11581404. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript PMID:11581404. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis PMID:22733359.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• ERVK-16
• ERVK-21
• HERV-K104
• HERVK_113
• HERVK_113