Seroatlas · Human Serome Atlas

ERVK-21

Endogenous retrovirus group K member 21 Env polyprotein

Also known as: ENK21_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61565
Gene: ERVK-21
Canonical length: 698 aa

OverviewNCBI Gene

No narrative summary is available for ERVK-21 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

698 residues, UniProt reviewed canonical sequence.

>P61565|ERVK-21
     1  MHPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEQMKLPS TKKAEPPTWA QLKKLTQLAT
    61  KYLENTKVTQ TPESMLLAAL MIVSMVVSLP MPAGAAAANY TNWAYVPFPP LIRAVTWMDN
   121  PIEVYVNDSV WVHGPIDDRC PAKPEEEGMM INISIGYHYP PICLGRAPGC LMPAVQNWLV
   181  EVPTVSPISR FTYNMVSGMS LRPRVNYLQD FSYQRSLKFR PKGKPCPKEI PKESKNTEVL
   241  VWEECVANSV VILQNNEFGT IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK
   301  HKHKKLQSFY PWEWGEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI WSGNQTLETR
   361  DRKPFYTVDL NSSLTVPLQS CVKPPYMLVV GNIVIKPDSQ TITCENCRLL TCIDSTFNWQ
   421  HRILLVRARE GVWIPVSMDR PWEASPSIHI LTEVLKGVLN RSKRFIFTLI AVIMGLIAVT
   481  AMAAVAGVAL HSFVQSVNFV NDWQKNSTRL WNSQSSIDQK LANQINDLRQ TVIWMGDRLM
   541  SLEHRFQLQC DWNTSDFCIT PQIYNESEHH WDMVRRHLQG REDNLTLDIS KLKEQIFEAS
   601  KAHLNLVPGT EAIAGVADGL ANLNPVTWVK TIGSTTIINL ILILVCLFCL LLVCRCTQQL
   661  RRDSDHRERA MMTMVVLSKR KGGNVGKSKR DQIVTVSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVK-21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37

OntologyGO

Molecular functions

structural molecule activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVK-21 as an antibody target. Whether an autoantibody or antibody against ERVK-21 could matter depends on whether native ERVK-21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVK-21 is annotated at the cell surface, where native ERVK-21 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERVK-21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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