Seroatlas · Human Serome Atlas

HERV-K104

Endogenous retrovirus group K member 104 Rec protein

Also known as: REC04_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61576
Gene: HERV-K104
Canonical length: 105 aa
Quaternary structure: Homotetramer

OverviewNCBI Gene

No narrative summary is available for HERV-K104 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>P61576|HERV-K104
     1  MNPSEMQRKA PPRRRRHCNR APLTHKMNKM VTSEEEMKLP STKKAEPLTW AQLKKLTQLA
    61  TKCLENTKVT QTPESMLLAA LMIVSMVSAG VTNSSKETAT IENGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HERV-K104 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6

OntologyGO

Biological processes

mRNA transport

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HERV-K104 as an antibody target. Whether an autoantibody or antibody against HERV-K104 could matter depends on whether native HERV-K104 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HERV-K104 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HERV-K104 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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