Seroatlas · Human Serome Atlas

HERVK_113

Endogenous retrovirus group K member 113 Rec protein

Also known as: RE113_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61574
Gene: HERVK_113
Canonical length: 105 aa
Quaternary structure: Homotetramer

OverviewNCBI Gene

No narrative summary is available for HERVK_113 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>P61574|HERVK_113
     1  MNPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEEQMKLP STKKAEPPTW AQLKKLTQLA
    61  TKYLENTKVT QTPESMLLAA LMIVSMVSAG VPNSSEETAT IENGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HERVK_113 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58

OntologyGO

Biological processes

mRNA transport

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HERVK_113 as an antibody target. Whether an autoantibody or antibody against HERVK_113 could matter depends on whether native HERVK_113 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HERVK_113 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HERVK_113 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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