Seroatlas · Human Serome Atlas

HERVK_113

Endogenous retrovirus group K member 113 Env polyprotein

Also known as: EN113_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q902F9
Gene: HERVK_113
Canonical length: 699 aa

OverviewNCBI Gene

No narrative summary is available for HERVK_113 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>Q902F9|HERVK_113
     1  MNPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEEQMKLP STKKAEPPTW AQLKKLTQLA
    61  TKYLENTKVT QTPESMLLAA LMIVSMVVSL PMPAGAAAAN YTYWAYVPFP PLIRAVTWMD
   121  NPIEVYVNDS VWVPGPTDDH CPAKPEEEGM MINISIGYRY PPICLGRAPG CLMPAVQNWL
   181  VEVPTVSPIS RFTYHMVSGM SLRPRVNYLQ DFSYQRSFKF RPKGKPCPKE IPKESKNTEV
   241  LVWEECVANS AVILQNNEFG TIIDWAPRGQ FYHNCSGQTQ SCPSAQVSPA VDSDLTESLD
   301  KHKHKKLQSF YPWEWGEKGI STPRPKIISP VSGPEHPELW RLTVASHHIR IWSGNQTLET
   361  RDRKPFYTVD LNSSLTVPLQ SCIKPPYMLV VGNIVIKPDS QTITCENCRL LTCIDSTFNW
   421  QHRILLVRAR EGVWIPVSMD RPWEASPSIH TLTEVLKGVL NRSKRFIFTL IAVIMGLIAV
   481  TATAAVAGVA LHSSVQSVNF VNDWQKNSTR LWNSQSSIDQ KLANQINDLR QTVIWMGDRL
   541  MSLEHRFQLQ CDWNTSDFSI TPQIYNESEH HWDMVRRHLQ GREDNLTLDI SKLKEQIFEA
   601  SKAHLNLVPG TEAIAGVADG LANLNPVTWV KTIGSTTIIN LILILVCLFC LLLVCRCTQQ
   661  LRRDSDHRER AMMTMAVLSK RKGGNVGKSK RDQIVTVSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HERVK_113 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37

OntologyGO

Molecular functions

structural molecule activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HERVK_113 as an antibody target. Whether an autoantibody or antibody against HERVK_113 could matter depends on whether native HERVK_113 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HERVK_113 is annotated at the cell surface, where native HERVK_113 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HERVK_113 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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