Got1/Sft2-like family
PF04178
Definition
Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events PMID:10406798. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein ([swissprot:P38166]) PMID:7596416. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments PMID:10406798.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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