Seroatlas · Human Serome Atlas

GOLT1A

Vesicle transport protein GOT1A

Also known as: CGI-141, FLJ42654, GOT1, GOT1A_HUMAN, MGC62027, YMR292W

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZVE7
Gene
GOLT1A
Ensembl
ENSG00000174567
Chromosome
1
Canonical length
132 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus subcompartment; endoplasmic reticulum; and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q6ZVE7|GOLT1A
     1  MISITEWQKI GVGITGFGIF FILFGTLLYF DSVLLAFGNL LFLTGLSLII GLRKTFWFFF
    61  QRHKLKGTSF LLGGVVIVLL RWPLLGMFLE TYGFFSLFKG FFPVAFGFLG NVCNIPFLGA
   121  LFRRLQGTSS MV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLT1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
217 nTPM

Expression across tissuesHPA

Tissue

  • liver: 217 nTPM
  • duodenum: 45 nTPM
  • small intestine: 43 nTPM
  • pituitary gland: 33 nTPM
  • basal ganglia: 31 nTPM
  • pancreas: 25 nTPM

Single-cell type

  • enterocytes: 202 nCPM
  • hepatocytes: 163 nCPM
  • urothelial cells: 65 nCPM
  • pancreatic islet cells: 54 nCPM
  • cholangiocytes: 47 nCPM
  • syncytiotrophoblasts: 41 nCPM

Immune cell

  • MAIT T-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • hypothalamus: 21 nTPM
  • basal ganglia: 16 nTPM
  • thalamus: 12 nTPM
  • cerebellum: 12 nTPM
  • amygdala: 9.7 nTPM
  • midbrain: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0.24
gnomAD missense Z
0.6
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLT1A as an antibody target. Whether an autoantibody or antibody against GOLT1A could matter depends on whether native GOLT1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLT1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLT1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GOLT1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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