Seroatlas · Human Serome Atlas

SFT2D1

Vesicle transport protein SFT2A

Also known as: C6orf83, MGC19825, pRGR1, SFT2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV19
Gene: SFT2D1
Ensembl: ENSG00000198818
Chromosome: 6
Canonical length: 159 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to be involved in protein transport and vesicle-mediated transport. Predicted to be located in several cellular components, including cytoplasm; endomembrane system; and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q8WV19|SFT2D1
     1  MEKLRRVLSG QDDEEQGLTA QVLDASSLSF NTRLKWFAIC FVCGVFFSIL GTGLLWLPGG
    61  IKLFAVFYTL GNLAALASTC FLMGPVKQLK KMFEATRLLA TIVMLLCFIF TLCAALWWHK
   121  KGLAVLFCIL QFLSMTWYSL SYIPYARDAV IKCCSSLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFT2D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 114 nTPM
midbrain: 70 nTPM
salivary gland: 67 nTPM
epididymis: 64 nTPM
hippocampal formation: 60 nTPM
amygdala: 58 nTPM

Single-cell type

gastric progenitor cells: 465 nCPM
neutrophils: 450 nCPM
extravillous trophoblasts: 357 nCPM
esophageal apical cells: 283 nCPM
hofbauer cells: 266 nCPM
kupffer cells: 261 nCPM

Immune cell

plasmacytoid DC: 205 nTPM
neutrophil: 167 nTPM
basophil: 142 nTPM
eosinophil: 127 nTPM
non-classical monocyte: 108 nTPM
myeloid DC: 103 nTPM

Brain region

white matter: 57 nTPM
medulla oblongata: 43 nTPM
spinal cord: 39 nTPM
cerebellum: 37 nTPM
basal ganglia: 35 nTPM
pons: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFT2D1 as an antibody target. Whether an autoantibody or antibody against SFT2D1 could matter depends on whether native SFT2D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFT2D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SFT2D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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