SFT2D2

Protein identityUniProt · HPA

UniProt accession

O95562

Gene

SFT2D2

Ensembl

ENSG00000213064

Chromosome

1

Canonical length

160 aa

Protein class

Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in protein transport and vesicle-mediated transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>O95562|SFT2D2
     1  MDKLKKVLSG QDTEDRSGLS EVVEASSLSW STRIKGFIAC FAIGILCSLL GTVLLWVPRK
    61  GLHLFAVFYT FGNIASIGST IFLMGPVKQL KRMFEPTRLI ATIMVLLCFA LTLCSAFWWH
   121  NKGLALIFCI LQSLALTWYS LSFIPFARDA VKKCFAVCLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFT2D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

30 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for SFT2D2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.9

gnomAD pLI

0.01

gnomAD missense Z

-0.16

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein transport
• vesicle-mediated transport

Cellular components

• cytoplasm
• endomembrane system
• extracellular exosome
• membrane

Protein domainsUniProt · Pfam · InterPro

• Vesicle transport protein, Got1/SFT2-like
• Vesicle transport protein SFT2
• Got1/Sft2-like family

KeywordsUniProt

• Acetylation
• Membrane
• Phosphoprotein
• Protein transport
• Transmembrane
• Transmembrane helix
• Transport