Hr1 repeat

Definition

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) PMID:7851406. The first two of these repeats were later shown to bind the small G protein rho [[cite:PMID:8647255],[cite:PMID:9446575]] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography PMID:10619026. It forms an antiparallel coiled-coil fold termed an ACC finger.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• PKN1
• PKN2
• PKN3
• RHPN1
• RHPN2