Seroatlas · Human Serome Atlas

RHBDD3

Rhomboid domain-containing protein 3

Also known as: C22orf3, PTAG, RHBD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3P4
Gene: RHBDD3
Ensembl: ENSG00000100263
Chromosome: 22
Canonical length: 386 aa
Protein class: Predicted membrane proteins
Subcellular location: Microtubules

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within several processes, including MAPK cascade; negative regulation of natural killer cell activation; and positive regulation of protein catabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q9Y3P4|RHBDD3
     1  MHARGPHGQL SPALPLASSV LMLLMSTLWL VGAGPGLVLA PELLLDPWQV HRLLTHALGH
    61  TALPGLLLSL LLLPTVGWQQ ECHLGTLRFL HASALLALAS GLLAVLLAGL GLSSAAGSCG
   121  YMPVHLAMLA GEGHRPRRPR GALPPWLSPW LLLALTPLLS SEPPFLQLLC GLLAGLAYAA
   181  GAFRWLEPSE RRLQVLQEGV LCRTLAGCWP LRLLATPGSL AELPVTHPAG VRPPIPGPPY
   241  VASPDLWSHW EDSALPPPSL RPVQPTWEGS SEAGLDWAGA SFSPGTPMWA ALDEQMLQEG
   301  IQASLLDGPA QEPQSAPWLS KSSVSSLRLQ QLERMGFPTE QAVVALAATG RVEGAVSLLV
   361  GGQVGTETLV THGKGGPAHS EGPGPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHBDD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
adrenal gland: 20 nTPM
cerebellum: 16 nTPM
liver: 16 nTPM
pituitary gland: 15 nTPM
hypothalamus: 13 nTPM

Single-cell type

cytotrophoblasts: 67 nCPM
syncytiotrophoblasts: 55 nCPM
differentiating spermatogonia: 42 nCPM
early primary spermatocytes: 39 nCPM
endometrial luminal cells: 39 nCPM
myonuclei: 37 nCPM

Immune cell

plasmacytoid DC: 11 nTPM
myeloid DC: 4.7 nTPM
classical monocyte: 4.6 nTPM
intermediate monocyte: 4.1 nTPM
non-classical monocyte: 3.9 nTPM
T-reg: 3.9 nTPM

Brain region

medulla oblongata: 14 nTPM
midbrain: 13 nTPM
pons: 12 nTPM
basal ganglia: 12 nTPM
white matter: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHBDD3 as an antibody target. Whether an autoantibody or antibody against RHBDD3 could matter depends on whether native RHBDD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHBDD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHBDD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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