Seroatlas · Human Serome Atlas

RHBDL3

Rhomboid-related protein 3

Also known as: RHBDL4, RHBL3_HUMAN, VRHO

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P58872
Gene: RHBDL3
Ensembl: ENSG00000141314
Chromosome: 17
Canonical length: 404 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>P58872|RHBDL3
     1  MGEHPSPGPA VAACAEAERI EELEPEAEER LPAAPEDHWK VLFDQFDPGN TGYISTGKFR
    61  SLLESHSSKL DPHKREVLLA LADSHADGQI GYQDFVSLMS NKRSNSFRQA ILQGNRRLSS
   121  KALLEEKGLS LSQRLIRHVA YETLPREIDR KWYYDSYTCC PPPWFMITVT LLEVAFFLYN
   181  GVSLGQFVLQ VTHPRYLKNS LVYHPQLRAQ VWRYLTYIFM HAGIEHLGLN VVLQLLVGVP
   241  LEMVHGATRI GLVYVAGVVA GSLAVSVADM TAPVVGSSGG VYALVSAHLA NIVMNWSGMK
   301  CQFKLLRMAV ALICMSMEFG RAVWLRFHPS AYPPCPHPSF VAHLGGVAVG ITLGVVVLRN
   361  YEQRLQDQSL WWIFVAMYTV FVLFAVFWNI FAYTLLDLKL PPPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHBDL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

retina: 24 nTPM
cerebral cortex: 19 nTPM
hippocampal formation: 16 nTPM
heart muscle: 14 nTPM
midbrain: 13 nTPM
basal ganglia: 11 nTPM

Single-cell type

retinal horizontal cells: 767 nCPM
rod photoreceptor cells: 318 nCPM
retinal ganglion cells: 263 nCPM
oligodendrocyte progenitor cells: 165 nCPM
retinal bipolar cells: 119 nCPM
cone photoreceptor cells: 112 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 43 nTPM
midbrain: 36 nTPM
pons: 28 nTPM
white matter: 26 nTPM
cerebellum: 25 nTPM
medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHBDL3 as an antibody target. Whether an autoantibody or antibody against RHBDL3 could matter depends on whether native RHBDL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHBDL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHBDL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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