CBS domain
PF00571
Definition
CBS domains are small intracellular modules that pair together to form a stable globular domain PMID:10200156. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain PMID:14722609. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet PMID:14722619. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet PMID:11524006. CBS domain pairs from AMPK bind AMP or ATP PMID:14722619. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP PMID:14722619.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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