Rec21/ENK19
IPR059105
Definition
This entry represents Rec21 proteins. This domain can be found covering the total length of Rec21 or at the N-terminal in ENK19 and related animal proteins. REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homologue of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts PMID:11581404. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript PMID:11581404. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis PMID:22733359. ENK19 is an endogenous retroviral envelope protein. Retroviral envelope proteins typically mediate receptor recognition and membrane fusion during the early stages of infection; however, endogenous copies may retain, lose, or acquire modified functions through evolution. ENK19 has lost its original fusogenic activity, suggesting it no longer contributes to membrane fusion but may have adopted alternative roles or become functionally inert PMID:14557543.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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