Extracellular Matrix Regulatory Proteins
IPR050991
Definition
This family of proteins is involved in the composition and function of the extracellular matrix (ECM). They play a crucial role in cell-matrix interactions, influencing cellular behaviors such as adhesion, motility, differentiation, and neurite outgrowth. These proteins interact with various cells and matrix components, modulating processes like synaptic plasticity, neuronal regeneration, and angiogenesis. They are implicated in the regulation of integrin-mediated cell adhesion, affecting phosphorylation and cell detachment. Additionally, they participate in the development and maintenance of the nervous system, including the clustering and regulation of sodium channels at nodes of Ranvier. Some family members are associated with tumor growth and metastasis, acting as ligands for multiple integrins and influencing cell migration and angiogenesis.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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