TNR

Protein identityUniProt · HPA

UniProt accession

Q92752

Gene

TNR

Ensembl

ENSG00000116147

Chromosome

1

Canonical length

1358 aa

Protein class

Disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted in brain

OverviewNCBI Gene

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

1358 residues, UniProt reviewed canonical sequence.

>Q92752|TNR
     1  MGADGETVVL KNMLIGINLI LLGSMIKPSE CQLEVTTERV QRQSVEEEGG IANYNTSSKE
    61  QPVVFNHVYN INVPLDNLCS SGLEASAEQE VSAEDETLAE YMGQTSDHES QVTFTHRINF
   121  PKKACPCASS AQVLQELLSR IEMLEREVSV LRDQCNANCC QESAATGQLD YIPHCSGHGN
   181  FSFESCGCIC NEGWFGKNCS EPYCPLGCSS RGVCVDGQCI CDSEYSGDDC SELRCPTDCS
   241  SRGLCVDGEC VCEEPYTGED CRELRCPGDC SGKGRCANGT CLCEEGYVGE DCGQRQCLNA
   301  CSGRGQCEEG LCVCEEGYQG PDCSAVAPPE DLRVAGISDR SIELEWDGPM AVTEYVISYQ
   361  PTALGGLQLQ QRVPGDWSGV TITELEPGLT YNISVYAVIS NILSLPITAK VATHLSTPQG
   421  LQFKTITETT VEVQWEPFSF SFDGWEISFI PKNNEGGVIA QVPSDVTSFN QTGLKPGEEY
   481  IVNVVALKEQ ARSPPTSASV STVIDGPTQI LVRDVSDTVA FVEWIPPRAK VDFILLKYGL
   541  VGGEGGRTTF RLQPPLSQYS VQALRPGSRY EVSVSAVRGT NESDSATTQF TTEIDAPKNL
   601  RVGSRTATSL DLEWDNSEAE VQEYKVVYST LAGEQYHEVL VPRGIGPTTR ATLTDLVPGT
   661  EYGVGISAVM NSQQSVPATM NARTELDSPR DLMVTASSET SISLIWTKAS GPIDHYRITF
   721  TPSSGIASEV TVPKDRTSYT LTDLEPGAEY IISVTAERGR QQSLESTVDA FTGFRPISHL
   781  HFSHVTSSSV NITWSDPSPP ADRLILNYSP RDEEEEMMEV SLDATKRHAV LMGLQPATEY
   841  IVNLVAVHGT VTSEPIVGSI TTGIDPPKDI TISNVTKDSV MVSWSPPVAS FDYYRVSYRP
   901  TQVGRLDSSV VPNTVTEFTI TRLNPATEYE ISLNSVRGRE ESERICTLVH TAMDNPVDLI
   961  ATNITPTEAL LQWKAPVGEV ENYVIVLTHF AVAGETILVD GVSEEFRLVD LLPSTHYTAT
  1021  MYATNGPLTS GTISTNFSTL LDPPANLTAS EVTRQSALIS WQPPRAEIEN YVLTYKSTDG
  1081  SRKELIVDAE DTWIRLEGLL ENTDYTVLLQ AAQDTTWSSI TSTAFTTGGR VFPHPQDCAQ
  1141  HLMNGDTLSG VYPIFLNGEL SQKLQVYCDM TTDGGGWIVF QRRQNGQTDF FRKWADYRVG
  1201  FGNVEDEFWL GLDNIHRITS QGRYELRVDM RDGQEAAFAS YDRFSVEDSR NLYKLRIGSY
  1261  NGTAGDSLSY HQGRPFSTED RDNDVAVTNC AMSYKGAWWY KNCHRTNLNG KYGESRHSQG
  1321  INWYHWKGHE FSIPFVEMKM RPYNHRLMAG RKRQSLQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

39 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNR.

Disease | AllUniProt

Conditions TNR is implicated in, by any mechanism.

• Neurodevelopmental disorder, non-progressive, with spasticity and transient opisthotonus (NEDSTO) MIM:619653

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 289 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus
• Non-progressive neurodevelopmental disorder with spasticity and transient opisthotonus
• Gastric cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.52

gnomAD missense Z

1.6

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• associative learning
• axon extension involved in regeneration
• axon guidance
• cell adhesion
• extracellular matrix organization
• locomotory exploration behavior
• long-term synaptic potentiation
• negative regulation of axon extension involved in regeneration
• negative regulation of cell-cell adhesion
• negative regulation of neuron projection development
• negative regulation of synaptic transmission
• nervous system development
• neuroblast migration
• neuromuscular process controlling balance
• neuron cell-cell adhesion
• positive regulation of synaptic transmission, glutamatergic
• positive regulation of transmission of nerve impulse
• regulation of cell adhesion
• regulation of cell differentiation
• regulation of cell migration
• synapse organization
• synaptic transmission, glutamatergic
• telencephalon cell migration

Cellular components

• cell surface
• extracellular matrix
• extracellular region
• extracellular space
• glutamatergic synapse
• membrane raft
• perineuronal net
• Schaffer collateral - CA1 synapse
• tenascin complex

Protein domainsUniProt · Pfam · InterPro

• EGF-like domain
• Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
• Fibronectin type III
• Immunoglobulin-like fold
• Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
• Fibrinogen-like, C-terminal
• Fibronectin type III superfamily
• Extracellular Matrix Regulatory Proteins
• Fibronectin type III domain
• Fibrinogen beta and gamma chains, C-terminal globular domain
• Teneurin-like EGF domain
• Teneurin EGF domain

KeywordsUniProt

• Cell adhesion
• Coiled coil
• Disulfide bond
• EGF-like domain
• Extracellular matrix
• Glycoprotein
• Phosphoprotein
• Proteoglycan
• Repeat
• Secreted
• Sialic acid
• Signal

InteractionsUniProt · HPA

Protein binding partners of TNR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ACAN
• BCAN
• CNTN1
• PTPRZ1
• SCN2B
• TNC
• FN1