Seroatlas · Human Serome Atlas

TNN

Tenascin-N

Also known as: TENN_HUMAN, TNW

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQP3
Gene
TNN
Ensembl
ENSG00000120332
Chromosome
1
Canonical length
1299 aa
Protein class
Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix
Quaternary structure
Homohexamer

OverviewNCBI Gene

Predicted to enable integrin binding activity. Involved in positive regulation of sprouting angiogenesis; regulation of cell adhesion; and regulation of cell migration. Located in collagen-containing extracellular matrix. Part of tenascin complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1299 residues, UniProt reviewed canonical sequence.

>Q9UQP3|TNN
     1  MSLQEMFRFP MGLLLGSVLL VASAPATLEP PGCSNKEQQV TVSHTYKIDV PKSALVQVDA
    61  DPQPLSDDGA SLLALGEARE EQNIIFRHNI RLQTPQKDCE LAGSVQDLLA RVKKLEEEMV
   121  EMKEQCSAQR CCQGVTDLSR HCSGHGTFSL ETCSCHCEEG REGPACERLA CPGACSGHGR
   181  CVDGRCLCHE PYVGADCGYP ACPENCSGHG ECVRGVCQCH EDFMSEDCSE KRCPGDCSGH
   241  GFCDTGECYC EEGFTGLDCA QVVTPQGLQL LKNTEDSLLV SWEPSSQVDH YLLSYYPLGK
   301  ELSGKQIQVP KEQHSYEILG LLPGTKYIVT LRNVKNEVSS SPQHLLATTD LAVLGTAWVT
   361  DETENSLDVE WENPSTEVDY YKLRYGPMTG QEVAEVTVPK SSDPKSRYDI TGLHPGTEYK
   421  ITVVPMRGEL EGKPILLNGR TEIDSPTNVV TDRVTEDTAT VSWDPVQAVI DKYVVRYTSA
   481  DGDTKEMAVH KDESSTVLTG LKPGEAYKVY VWAERGNQGS KKADTNALTE IDSPANLVTD
   541  RVTENTATIS WDPVQATIDK YVVRYTSADD QETREVLVGK EQSSTVLTGL RPGVEYTVHV
   601  WAQKGDRESK KADTNAPTDI DSPKNLVTDR VTENMATVSW DPVQAAIDKY VVRYTSAGGE
   661  TREVPVGKEQ SSTVLTGLRP GMEYMVHVWA QKGDQESKKA DTKAQTDIDS PQNLVTDRVT
   721  ENMATVSWDP VRATIDRYVV RYTSAKDGET REVPVGKEQS STVLTGLRPG VEYTVHVWAQ
   781  KGAQESKKAD TKAQTDIDSP QNLVTDWVTE NTATVSWDPV QATIDRYVVH YTSANGETRE
   841  VPVGKEQSST VLTGLRPGME YTVHVWAQKG NQESKKADTK AQTEIDGPKN LVTDWVTENM
   901  ATVSWDPVQA TIDKYMVRYT SADGETREVP VGKEHSSTVL TGLRPGMEYM VHVWAQKGAQ
   961  ESKKADTKAQ TELDPPRNLR PSAVTQSGGI LTWTPPSAQI HGYILTYQFP DGTVKEMQLG
  1021  REDQRFALQG LEQGATYPVS LVAFKGGRRS RNVSTTLSTV GARFPHPSDC SQVQQNSNAA
  1081  SGLYTIYLHG DASRPLQVYC DMETDGGGWI VFQRRNTGQL DFFKRWRSYV EGFGDPMKEF
  1141  WLGLDKLHNL TTGTPARYEV RVDLQTANES AYAIYDFFQV ASSKERYKLT VGKYRGTAGD
  1201  ALTYHNGWKF TTFDRDNDIA LSNCALTHHG GWWYKNCHLA NPNGRYGETK HSEGVNWEPW
  1261  KGHEFSIPYV ELKIRPHGYS REPVLGRKKR TLRGRLRTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 11 nTPM
  • breast: 4.6 nTPM
  • salivary gland: 3.1 nTPM
  • skin: 2.8 nTPM
  • pituitary gland: 1.8 nTPM
  • thyroid gland: 1.7 nTPM

Single-cell type

  • pericytes: 15 nCPM
  • salivary acinar cells: 13 nCPM
  • fibroblasts: 11 nCPM
  • mucous neck cells: 4 nCPM
  • late spermatids: 3.5 nCPM
  • schwann cells: 3.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.4 nTPM
  • choroid plexus: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • thalamus: 0.3 nTPM
  • hippocampal formation: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
-0.54
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNN as an antibody target. Whether an autoantibody or antibody against TNN could matter depends on whether native TNN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNN is annotated as secreted, so native TNN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TNN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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