Seroatlas · Human Serome Atlas

TNXA

Putative tenascin-XA

Also known as: TENXA_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16473
Gene: TNXA
Canonical length: 311 aa

OverviewNCBI Gene

No narrative summary is available for TNXA in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q16473|TNXA
     1  MEDKNGAPHG APHSDSPLGF SHAAPEEDTP APELAPEAPE PPEEPRLGVL TVTDTTPDSM
    61  RLSWSVAQGP FDSFVVQYED TNGQPQALLV DGDQSKILIS GLEPSTPYRF LLYGLHEGKR
   121  LGPLSAEGTT GLAPAGQTSE ESRPRLSQLS VTDVTTSSLR LNWEAPPGAF DSFLLRFGVP
   181  SPSTLEPHPR PLLQRELMVP GTRHSAVLRD LRSGTLYSLT LYGLRGPHKA DSIQGTARTL
   241  SPVLESPRDL QFSEIRETSA KVNWMPPPSR ADSFKVSYQL ADGGEPQSVQ VDGRARTQKL
   301  QFLTVPHSCV H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNXA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41

OntologyGO

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNXA as an antibody target. Whether an autoantibody or antibody against TNXA could matter depends on whether native TNXA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNXA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNXA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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