Seroatlas · Human Serome Atlas

CCN1

CCN family member 1

Also known as: CCN1_HUMAN, CYR61, GIG1, IGFBP10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00622
Gene: CCN1
Ensembl: ENSG00000142871
Chromosome: 1
Canonical length: 381 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>O00622|CCN1
     1  MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL
    61  NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ
   121  CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG
   181  KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS
   241  KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY
   301  AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP
   361  HANEAAFPFY RLFNDIHKFR D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 471 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 471 nTPM
adipose tissue: 378 nTPM
lung: 255 nTPM
fallopian tube: 253 nTPM
cervix: 240 nTPM
heart muscle: 225 nTPM

Single-cell type

decidual stromal cells: 1,900 nCPM
epididymal basal cells: 1,412 nCPM
hepatic stellate cells: 1,362 nCPM
epididymal efferent duct absorptive cells: 883 nCPM
migrating cytotrophoblasts: 879 nCPM
pancreatic duct cells: 774 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 57 nTPM
choroid plexus: 29 nTPM
thalamus: 21 nTPM
basal ganglia: 18 nTPM
medulla oblongata: 18 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.71
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCN1 as an antibody target. Whether an autoantibody or antibody against CCN1 could matter depends on whether native CCN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCN1 is annotated as secreted, so native CCN1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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