CCN5

Protein identityUniProt · HPA

UniProt accession

O76076

Gene

CCN5

Ensembl

ENSG00000064205

Chromosome

20

Canonical length

250 aa

Protein class

Plasma proteins, Predicted secreted proteins

Subcellular location

Plasma membrane

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>O76076|CCN5
     1  MRGTPKTHLL AFSLLCLLSK VRTQLCPTPC TCPWPPPRCP LGVPLVLDGC GCCRVCARRL
    61  GEPCDQLHVC DASQGLVCQP GAGPGGRGAL CLLAEDDSSC EVNGRLYREG ETFQPHCSIR
   121  CRCEDGGFTC VPLCSEDVRL PSWDCPHPRR VEVLGKCCPE WVCGQGGGLG TQPLPAQGPQ
   181  FSGLVSSLPP GVPCPEWSTA WGPCSTTCGL GMATRVSNQN RFCRLETQRR LCLSRPCPPS
   241  RGRSPQNSAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

904 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.46

gnomAD pLI

0

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• cell-cell signaling
• positive regulation of cell differentiation
• signal transduction

Molecular functions

• heparin binding
• integrin binding

Cellular components

• extracellular matrix
• extracellular space
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Insulin-like growth factor-binding protein, IGFBP
• Thrombospondin type-1 (TSP1) repeat
• VWFC domain
• Growth factor receptor cysteine-rich domain superfamily
• Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
• Thrombospondin type-1 repeat superfamily
• CCN, TSP1 domain
• Cellular Communication Network Factor
• von Willebrand factor type C domain
• Insulin-like growth factor binding protein
• CCN3 Nov like TSP1 domain

KeywordsUniProt

• Cell adhesion
• Disulfide bond
• Secreted
• Signal