CCN2

Protein identityUniProt · HPA

UniProt accession

P29279

Gene

CCN2

Ensembl

ENSG00000118523

Chromosome

6

Canonical length

349 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted secreted proteins

Subcellular location

Golgi apparatus,Vesicles

Secretome location

Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>P29279|CCN2
     1  MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC
    61  AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC
   121  KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA
   181  AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR
   241  PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT
   301  LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

1,230 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCN2.

Disease | AllUniProt

Conditions CCN2 is implicated in, by any mechanism.

• Kyphomelic dysplasia (KMD) MIM:211350
• Spondyloepimetaphyseal dysplasia, Li-Shao-Li type (SEMDLSL) MIM:621099

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 64 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Kyphomelic dysplasia
• Spondyloepimetaphyseal dysplasia, Li-Shao-Li type

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.06

gnomAD pLI

0

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• cartilage condensation
• cell adhesion
• cell migration
• cell-matrix adhesion
• chondrocyte differentiation
• chondrocyte proliferation
• DNA biosynthetic process
• epidermis development
• fibroblast growth factor receptor signaling pathway
• integrin-mediated signaling pathway
• lung development
• negative regulation of gene expression
• osteoblast differentiation
• positive regulation of cell differentiation
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of JNK cascade
• positive regulation of stress fiber assembly
• reactive oxygen species metabolic process
• regulation of chondrocyte differentiation
• response to wounding
• signal transduction
• tissue homeostasis

Molecular functions

• heparin binding
• insulin-like growth factor binding
• integrin binding

Cellular components

• extracellular matrix
• extracellular region
• extracellular space
• Golgi apparatus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Insulin-like growth factor-binding protein, IGFBP
• Thrombospondin type-1 (TSP1) repeat
• VWFC domain
• Cystine knot, C-terminal
• Glycoprotein hormone subunit beta
• Growth factor receptor cysteine-rich domain superfamily
• IGFBP-related, CNN
• Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
• Thrombospondin type-1 repeat superfamily
• CCN, TSP1 domain
• Cellular Communication Network Factor
• Cystine-knot domain
• von Willebrand factor type C domain
• Insulin-like growth factor binding protein
• CCN3 Nov like TSP1 domain

KeywordsUniProt

• Cell adhesion
• Disulfide bond
• DNA synthesis
• Dwarfism
• Extracellular matrix
• Glycoprotein
• Heparin-binding
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of CCN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TSKU