Zinc Finger C2H2-type Transcription Regulators
IPR050888
Definition
The Zinc Finger C2H2-type protein family is characterized by its involvement in transcriptional regulation, with members acting as transcriptional activators or repressors depending on the context. These proteins play pivotal roles in various biological processes, including BMP signaling, olfactory neurogenesis, gluconeogenesis regulation, cell fate determination, mRNA translation regulation, and morphogenesis. They interact with different molecules such as SMADs, EBF1, and DNA sequences to exert their functions. The family's versatility is highlighted by its participation in developmental switches, control of cell proliferation and differentiation, and response to oxidative stress. The domain architecture of these proteins typically includes multiple C2H2-type zinc fingers, which are key to their DNA-binding and protein-interaction capabilities.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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