ZFP3
Zinc finger protein 3 homolog
Also known as: FLJ30726, ZFP3_HUMAN, ZNF752
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96NJ6
- Gene
- ZFP3
- Ensembl
- ENSG00000180787
- Chromosome
- 17
- Canonical length
- 502 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
502 residues, UniProt reviewed canonical sequence.
>Q96NJ6|ZFP3
1 MGTENKEVIP KEEISEESEP HGSLLEKFPK VVYQGHEFGA GCEEDMLEGH SRESMEEVIE
61 QMSPQERDFP SGLMIFKKSP SSEKDRENNE SERGCSPSPN LVTHQGDTTE GVSAFATSGQ
121 NFLEILESNK TQRSSVGEKP HTCKECGKAF NQNSHLIQHM RVHSGEKPFE CKECGKTFGT
181 NSSLRRHLRI HAGEKPFACN ECGKAFIQSS HLIHHHRIHT GERPYKCEEC GKAFSQNSAL
241 ILHQRIHTGE KPYECNECGK TFRVSSQLIQ HQRIHTEERY HECNECGKAF KHSSGLIRHQ
301 KIHTGEKPYL CNECGKGFGQ SSELIRHQRI HTGDKPYECN ECGKTFGQNS EIIRHIRIHT
361 GEKPYVCKEC GKAFRGNSEL LRHERIHTGE KPYECFECGK AFRRTSHLIV HQRIHTGEKP
421 HQCNECARTF WDNSELLLHQ KIHIGEKPYE CSECEKTFSQ HSQLIIHQRI HTGEKPYECQ
481 ECQKTFSRSS HLLRHQSVHC MELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZFP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 9 nTPM
Expression across tissuesHPA
Tissue
- tongue: 9 nTPM
- parathyroid gland: 8.9 nTPM
- retina: 7.4 nTPM
- duodenum: 6.7 nTPM
- skeletal muscle: 6.7 nTPM
- heart muscle: 6.4 nTPM
Single-cell type
- cardiomyocytes: 31 nCPM
- respiratory ciliated cells: 26 nCPM
- myonuclei: 25 nCPM
- choroid plexus epithelial cells: 21 nCPM
- fallopian tube ciliated cells: 14 nCPM
- rod photoreceptor cells: 13 nCPM
Immune cell
- naive B-cell: 2.1 nTPM
- naive CD4 T-cell: 1.5 nTPM
- naive CD8 T-cell: 1.1 nTPM
- gdT-cell: 1 nTPM
- intermediate monocyte: 0.9 nTPM
- memory CD8 T-cell: 0.9 nTPM
Brain region
- choroid plexus: 17 nTPM
- cerebellum: 15 nTPM
- medulla oblongata: 11 nTPM
- midbrain: 11 nTPM
- thalamus: 10 nTPM
- basal ganglia: 9.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.49
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZFP3 as an antibody target. Whether an autoantibody or antibody against ZFP3 could matter depends on whether native ZFP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZFP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZFP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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