ZNF692
Zinc finger protein 692
Also known as: AREBP, FLJ20531, Zfp692, ZN692_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BU19
- Gene
- ZNF692
- Ensembl
- ENSG00000171163
- Chromosome
- 1
- Canonical length
- 519 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of gluconeogenesis. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
519 residues, UniProt reviewed canonical sequence.
>Q9BU19|ZNF692
1 MASSPAVDVS CRRREKRRQL DARRSKCRIR LGGHMEQWCL LKERLGFSLH SQLAKFLLDR
61 YTSSGCVLCA GPEPLPPKGL QYLVLLSHAH SRECSLVPGL RGPGGQDGGL VWECSAGHTF
121 SWGPSLSPTP SEAPKPASLP HTTRRSWCSE ATSGQELADL ESEHDERTQE ARLPRRVGPP
181 PETFPPPGEE EGEEEEDNDE DEEEMLSDAS LWTYSSSPDD SEPDAPRLLP SPVTCTPKEG
241 ETPPAPAALS SPLAVPALSA SSLSSRAPPP AEVRVQPQLS RTPQAAQQTE ALASTGSQAQ
301 SAPTPAWDED TAQIGPKRIR KAAKRELMPC DFPGCGRIFS NRQYLNHHKK YQHIHQKSFS
361 CPEPACGKSF NFKKHLKEHM KLHSDTRDYI CEFCARSFRT SSNLVIHRRI HTGEKPLQCE
421 ICGFTCRQKA SLNWHQRKHA ETVAALRFPC EFCGKRFEKP DSVAAHRSKS HPALLLAPQE
481 SPSGPLEPCP SISAPGPLGS SEGSRPSASP QAPTLLPQQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF692 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 51 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 51 nTPM
- testis: 38 nTPM
- prostate: 35 nTPM
- hippocampal formation: 31 nTPM
- cerebral cortex: 30 nTPM
- pituitary gland: 30 nTPM
Single-cell type
- late primary spermatocytes: 76 nCPM
- breast lactating cells: 47 nCPM
- astrocytes: 34 nCPM
- prostatic glandular cells: 32 nCPM
- myonuclei: 28 nCPM
- sertoli cells: 27 nCPM
Immune cell
- NK-cell: 8.1 nTPM
- naive CD4 T-cell: 4.1 nTPM
- memory CD8 T-cell: 4 nTPM
- gdT-cell: 3.6 nTPM
- T-reg: 3.5 nTPM
- neutrophil: 3.4 nTPM
Brain region
- pons: 15 nTPM
- white matter: 13 nTPM
- cerebral cortex: 12 nTPM
- basal ganglia: 12 nTPM
- cerebellum: 12 nTPM
- medulla oblongata: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.22
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.85
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- regulation of gluconeogenesis
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF692 as an antibody target. Whether an autoantibody or antibody against ZNF692 could matter depends on whether native ZNF692 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF692 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF692 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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