ZNF554
Zinc finger protein 554
Also known as: FLJ34817, ZN554_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86TJ5
- Gene
- ZNF554
- Ensembl
- ENSG00000172006
- Chromosome
- 19
- Canonical length
- 538 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
538 residues, UniProt reviewed canonical sequence.
>Q86TJ5|ZNF554
1 MVTCAHLGRR ARLPAAQPSA CPGTCFSQEE RMAAGYLPRW SQELVTFEDV SMDFSQEEWE
61 LLEPAQKNLY REVMLENYRN VVSLEALKNQ CTDVGIKEGP LSPAQTSQVT SLSSWTGYLL
121 FQPVASSHLE QREALWIEEK GTPQASCSDW MTVLRNQDST YKKVALQEEP ASGINMIKLI
181 REDGGWKQLE DSHEDPQGLL SQKASLHVVA VPQEKATAWH GFGENGNLSP ALVLSQGSSK
241 GNHLCGSELD ITSLASDSVL NHHQLGYADR RPCESNECGN AIRQNSHFIQ HGGKMFVYLE
301 NGQSLNHGMA LTIHNKINTA EKPFECHQCG KVFNRRHSLS EHQRIHTGEK PYECQECGRA
361 FTHSSTLTRH LRTHTGEKPY GCGECGKAFN RISSLTQHQR IHTGEKPYKC EDCGKSFCQS
421 SYLILHKRTH TGEKPYECSE CGKAFSDRSS LNQHERTHTG ENPYECKQCG RAFSQRSSLV
481 RHERTHTGEK PYRCQECGKA FSQSSSLVTH QKTHSSQKTY KIIDCGKAFY QNRHLIGYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF554 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 3.7 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 3.7 nTPM
- cerebral cortex: 3.1 nTPM
- basal ganglia: 2.6 nTPM
- hippocampal formation: 2.6 nTPM
- skeletal muscle: 2.6 nTPM
- hypothalamus: 2.5 nTPM
Single-cell type
- syncytiotrophoblasts: 24 nCPM
- adrenal medulla cells: 21 nCPM
- retinal ganglion cells: 16 nCPM
- differentiating spermatogonia: 14 nCPM
- myonuclei: 14 nCPM
- early primary spermatocytes: 13 nCPM
Immune cell
- plasmacytoid DC: 0.9 nTPM
- naive B-cell: 0.6 nTPM
- MAIT T-cell: 0.4 nTPM
- memory B-cell: 0.3 nTPM
- naive CD4 T-cell: 0.3 nTPM
- memory CD8 T-cell: 0.2 nTPM
Brain region
- cerebral cortex: 12 nTPM
- hypothalamus: 10 nTPM
- pons: 9.4 nTPM
- basal ganglia: 9.2 nTPM
- medulla oblongata: 9 nTPM
- cerebellum: 8.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.19
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.13
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF554 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF554 as an antibody target. Whether an autoantibody or antibody against ZNF554 could matter depends on whether native ZNF554 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF554 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF554 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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