Seroatlas · Human Serome Atlas

ZNF576

Zinc finger protein 576

Also known as: MGC2508, ZN576_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H609
Gene: ZNF576
Ensembl: ENSG00000124444
Chromosome: 19
Canonical length: 170 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>Q9H609|ZNF576
     1  MEDPNPEENM KQQDSPKERS PQSPGGNICH LGAPKCTRCL ITFADSKFQE RHMKREHPAD
    61  FVAQKLQGVL FICFTCARSF PSSKALITHQ RSHGPAAKPT LPVATTTAQP TFPCPDCGKT
   121  FGQAVSLRRH RQMHEVRAPP GTFACTECGQ DFAQEAGLHQ HYIRHARGEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF576 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

liver: 18 nTPM
cerebellum: 18 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 15 nTPM
prostate: 14 nTPM
pituitary gland: 14 nTPM

Single-cell type

late spermatids: 2.6 nCPM
conjunctival goblet cells: 1 nCPM
kupffer cells: 1 nCPM
salivary ionocytes: 0.7 nCPM
corticotrophs: 0.6 nCPM
hepatocytes: 0.6 nCPM

Immune cell

memory B-cell: 28 nTPM
plasmacytoid DC: 26 nTPM
NK-cell: 19 nTPM
T-reg: 19 nTPM
naive B-cell: 19 nTPM
naive CD4 T-cell: 19 nTPM

Brain region

cerebellum: 25 nTPM
thalamus: 25 nTPM
midbrain: 24 nTPM
medulla oblongata: 23 nTPM
pons: 23 nTPM
basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0
gnomAD missense Z: 1.15
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF576 as an antibody target. Whether an autoantibody or antibody against ZNF576 could matter depends on whether native ZNF576 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF576 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF576 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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