ELMOD1
ELMO domain-containing protein 1
Also known as: DKFZp547C176, ELMD1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N336
- Gene
- ELMOD1
- Ensembl
- ENSG00000110675
- Chromosome
- 11
- Canonical length
- 334 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Vesicles,Cytosol
OverviewNCBI Gene
Enables GTPase activator activity. Predicted to act upstream of or within cilium assembly and protein transport. Predicted to be active in Golgi apparatus; cilium; and glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
334 residues, UniProt reviewed canonical sequence.
>Q8N336|ELMOD1
1 MKHFLRMLIQ VCLYFYCKFL WRCLKFVMRK LTGRCELQRI CYNTKPGASR TMKIETSLRD
61 SKSKLLQTSV SVHPDAIEKT IEDIMELKKI NPDVNPQLGI SLQACLLQIV GYRNLIADVE
121 KLRREAYDSD NPQHEEMLLK LWKFLKPNTP LESRISKQWC EIGFQGDDPK TDFRGMGLLG
181 LYNLQYFAER DATAAQQVLS DSLHPKCRDI TKEEISKFSK AEWEKKRMDK AIGYSFAIVG
241 INITDLAYNL LVSGALKTHF YNIAPEAPTL SHFQQTFCYL MHEFHKFWIE EDPMDIMEFN
301 RVREKFRKRI IKQLQNPDMA LCPHFAASEG LINMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ELMOD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 52 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 52 nTPM
- cerebral cortex: 40 nTPM
- retina: 30 nTPM
- skin: 27 nTPM
- hypothalamus: 26 nTPM
- cerebellum: 24 nTPM
Single-cell type
- somatotrophs: 334 nCPM
- brain inhibitory neurons: 268 nCPM
- thyrotrophs: 158 nCPM
- brain excitatory neurons: 136 nCPM
- oligodendrocyte progenitor cells: 124 nCPM
- lactotrophs: 121 nCPM
Immune cell
- basophil: 0.3 nTPM
- neutrophil: 0.3 nTPM
- NK-cell: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
- memory B-cell: 0.1 nTPM
Brain region
- cerebral cortex: 99 nTPM
- basal ganglia: 88 nTPM
- midbrain: 83 nTPM
- hippocampal formation: 83 nTPM
- hypothalamus: 82 nTPM
- thalamus: 71 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.42
- gnomAD pLI
- 0.79
- gnomAD missense Z
- 0.98
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ELMOD1 as an antibody target. Whether an autoantibody or antibody against ELMOD1 could matter depends on whether native ELMOD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ELMOD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ELMOD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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