Sulfatase enzyme
IPR050738
Definition
The sulfatase family encompasses enzymes that hydrolyze sulfate esters from various substrates, including complex carbohydrates, steroids, and aromatic compounds. Members of the family are involved in diverse biological processes such as degradation of glycosaminoglycans, mineralization of sulfates, and conversion of sulfated steroid precursors to active steroids. Some sulfatases are implicated in the degradation of ulvan, a polysaccharide in green seaweed, while others are active towards artificial substrates like 4-methylumbelliferyl sulfate. Arylsulfatases, a subset within the family, hydrolyze sulfate from aromatic compounds, playing roles in cellular processes and environmental sulfate turnover. The family's activity is regulated by factors like phosphate, which can inhibit some members by forming a covalent bond with the active site 3-oxoalanine. The sulfatase family is essential for various organisms, from bacteria to humans, for maintaining sulfate homeostasis and processing sulfated molecules.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...