Histidine Acid Phosphatase
IPR050645
Definition
The Histidine Acid Phosphatase family comprises enzymes with diverse functions including hydrolysis of phosphomonoesters, dephosphorylation of proteins, and regulation of glycosaminoglycan chain maturation. Members are involved in normal growth, development, and differentiation processes such as gut differentiation and odontogenesis. Some are implicated in the hydrolysis of lysophosphatidic acid, contributing to lipid metabolism, while others participate in the dephosphorylation of xylose in proteoglycan linkage regions, influencing glycosaminoglycan synthesis. Certain family members have roles in pain suppression, tumor suppression in prostate cancer, and even in the enhancement of viral infection. The family's enzymes are characterized by their activity under acidic conditions and are regulated by various factors including tartrate and cAMP.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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