Seroatlas · Human Serome Atlas

ACP6

Lysophosphatidic acid phosphatase type 6

Also known as: ACPL1, LPAP, PPA6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPH0
Gene: ACP6
Ensembl: ENSG00000162836
Chromosome: 1
Canonical length: 428 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q9NPH0|ACP6
     1  MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGQ CPVDRSLLKL KMVQVVFRHG
    61  ARSPLKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP KPYSPYDSQY HETTLKGGMF
   121  AGQLTKVGMQ QMFALGERLR KNYVEDIPFL SPTFNPQEVF IRSTNIFRNL ESTRCLLAGL
   181  FQCQKEGPII IHTDEADSEV LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG
   241  IDSSDKVDFF ILLDNVAAEQ AHNLPSCPML KRFARMIEQR AVDTSLYILP KEDRESLQMA
   301  VGPFLHILES NLLKAMDSAT APDKIRKLYL YAAHDVTFIP LLMTLGIFDH KWPPFAVDLT
   361  MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN AMSVYTLSPE KYHALCSQTQ
   421  VMEVGNEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 21 nTPM
choroid plexus: 20 nTPM
breast: 17 nTPM
kidney: 16 nTPM
epididymis: 15 nTPM
thyroid gland: 15 nTPM

Single-cell type

astrocytes: 91 nCPM
distal convoluted tubule cells: 67 nCPM
bergmann glia: 62 nCPM
neutrophil progenitors: 59 nCPM
loop of henle epithelial cells: 59 nCPM
gonadotrophs: 56 nCPM

Immune cell

T-reg: 15 nTPM
eosinophil: 14 nTPM
naive CD4 T-cell: 8.2 nTPM
MAIT T-cell: 7.9 nTPM
memory CD4 T-cell: 7.5 nTPM
naive CD8 T-cell: 7.1 nTPM

Brain region

choroid plexus: 17 nTPM
midbrain: 16 nTPM
cerebral cortex: 14 nTPM
hypothalamus: 14 nTPM
medulla oblongata: 14 nTPM
thalamus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACP6.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 90 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cerebral visual impairment and intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACP6 as an antibody target. Whether an autoantibody or antibody against ACP6 could matter depends on whether native ACP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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