Seroatlas · Human Serome Atlas

PXYLP1

2-phosphoxylose phosphatase 1

Also known as: ACPL2, FLJ23751, PXYP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TE99
Gene: PXYLP1
Ensembl: ENSG00000155893
Chromosome: 3
Canonical length: 480 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables phosphatase activity. Involved in chondroitin sulfate proteoglycan biosynthetic process and positive regulation of heparan sulfate proteoglycan biosynthetic process. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>Q8TE99|PXYLP1
     1  MLFRNRFLLL LALAALLAFV SLSLQFFHLI PVSTPKNGMS SKSRKRIMPD PVTEPPVTDP
    61  VYEALLYCNI PSVAERSMEG HAPHHFKLVS VHVFIRHGDR YPLYVIPKTK RPEIDCTLVA
   121  NRKPYHPKLE AFISHMSKGS GASFESPLNS LPLYPNHPLC EMGELTQTGV VQHLQNGQLL
   181  RDIYLKKHKL LPNDWSADQL YLETTGKSRT LQSGLALLYG FLPDFDWKKI YFRHQPSALF
   241  CSGSCYCPVR NQYLEKEQRR QYLLRLKNSQ LEKTYGEMAK IVDVPTKQLR AANPIDSMLC
   301  HFCHNVSFPC TRNGCVDMEH FKVIKTHQIE DERERREKKL YFGYSLLGAH PILNQTIGRM
   361  QRATEGRKEE LFALYSAHDV TLSPVLSALG LSEARFPRFA ARLIFELWQD REKPSEHSVR
   421  ILYNGVDVTF HTSFCQDHHK RSPKPMCPLE NLVRFVKRDM FVALGGSGTN YYDACHREGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PXYLP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 140 nTPM

Expression across tissuesHPA

Tissue

epididymis: 140 nTPM
thymus: 50 nTPM
seminal vesicle: 27 nTPM
placenta: 17 nTPM
retina: 17 nTPM
parathyroid gland: 15 nTPM

Single-cell type

late primary spermatocytes: 288 nCPM
epididymal principal cells: 276 nCPM
early spermatids: 177 nCPM
late spermatids: 165 nCPM
renal collecting duct principal cells: 119 nCPM
neutrophils: 76 nCPM

Immune cell

naive CD4 T-cell: 22 nTPM
NK-cell: 19 nTPM
naive CD8 T-cell: 18 nTPM
basophil: 15 nTPM
gdT-cell: 14 nTPM
eosinophil: 9.4 nTPM

Brain region

cerebral cortex: 39 nTPM
hypothalamus: 26 nTPM
white matter: 25 nTPM
basal ganglia: 24 nTPM
amygdala: 23 nTPM
hippocampal formation: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PXYLP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

B3GAT3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PXYLP1 as an antibody target. Whether an autoantibody or antibody against PXYLP1 could matter depends on whether native PXYLP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PXYLP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PXYLP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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