Seroatlas · Human Serome Atlas

ACP3

Prostatic acid phosphatase

Also known as: ACP-3, ACPP, PAP, PPAP_HUMAN, TM-PAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P15309
Gene: ACP3
Ensembl: ENSG00000014257
Chromosome: 3
Canonical length: 386 aa
Protein class: Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>P15309|ACP3
     1  MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI DTFPTDPIKE
    61  SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE QVYIRSTDVD RTLMSAMTNL
   121  AALFPPEGVS IWNPILLWQP IPVHTVPLSE DQLLYLPFRN CPRFQELESE TLKSEEFQKR
   181  LHPYKDFIAT LGKLSGLHGQ DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE
   241  LSLLSLYGIH KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL
   301  DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS CPLERFAELV
   361  GPVIPQDWST ECMTTNSHQG TEDSTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 3,410 nTPM

Expression across tissuesHPA

Tissue

prostate: 3,410 nTPM
esophagus: 43 nTPM
kidney: 27 nTPM
skin: 26 nTPM
bone marrow: 17 nTPM
epididymis: 16 nTPM

Single-cell type

prostatic glandular cells: 24,145 nCPM
basal prostatic cells: 266 nCPM
prostatic club cells: 236 nCPM
esophageal apical cells: 143 nCPM
loop of henle epithelial cells: 122 nCPM
esophageal suprabasal cells: 93 nCPM

Immune cell

eosinophil: 140 nTPM
myeloid DC: 35 nTPM
classical monocyte: 30 nTPM
intermediate monocyte: 27 nTPM
neutrophil: 27 nTPM
non-classical monocyte: 26 nTPM

Brain region

white matter: 3.8 nTPM
hypothalamus: 3.7 nTPM
medulla oblongata: 3.5 nTPM
pons: 3.1 nTPM
cerebral cortex: 3 nTPM
choroid plexus: 3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACP3.

Disease | ImmuneIEDB

Conditions an epitope on ACP3 was assayed in.

prostate cancer B and T cell
castration-resistant prostate carcinoma B and T cell
prostatitis T cell
cancer B and T cell
esophageal cancer B and T cell
carcinoma B and T cell
colorectal cancer B and T cell
prostatic urethral cancer B and T cell
pancreatic carcinoma B cell
biliary tract cancer B and T cell
lung small cell carcinoma B cell
adult hepatocellular carcinoma B cell
triple-receptor negative breast cancer B and T cell
Her2-receptor negative breast cancer B and T cell
Her2-receptor positive breast cancer B and T cell
hematologic cancer B cell
hepatocellular carcinoma B cell
leiomyosarcoma B and T cell
liposarcoma B and T cell
osteosarcoma B and T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

5'-nucleotidase activity
acid phosphatase activity
choline binding
identical protein binding
lysophosphatidic acid phosphatase activity
molecular adaptor activity
phosphatase activity
protein homodimerization activity
protein tyrosine phosphatase activity
thiamine phosphate phosphatase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACP3 as an antibody target. Whether an autoantibody or antibody against ACP3 could matter depends on whether native ACP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACP3 is annotated at the cell surface, where native ACP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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