ACP4

Protein identityUniProt · HPA

UniProt accession

Q9BZG2

Gene

ACP4

Ensembl

ENSG00000142513

Chromosome

19

Canonical length

426 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins

Subcellular location

Nuclear bodies,Plasma membrane,Microtubules

Quaternary structure

Homodimer

OverviewNCBI Gene

Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q9BZG2|ACP4
     1  MAGLGFWGHP AGPLLLLLLL VLPPRALPEG PLVFVALVFR HGDRAPLASY PMDPHKEVAS
    61  TLWPRGLGQL TTEGVRQQLE LGRFLRSRYE AFLSPEYRRE EVYIRSTDFD RTLESAQANL
   121  AGLFPEAAPG SPEARWRPIP VHTVPVAEDK LLRFPMRSCP RYHELLREAT EAAEYQEALE
   181  GWTGFLSRLE NFTGLSLVGE PLRRAWKVLD TLMCQQAHGL PLPAWASPDV LRTLAQISAL
   241  DIGAHVGPPR AAEKAQLTGG ILLNAILANF SRVQRLGLPL KMVMYSAHDS TLLALQGALG
   301  LYDGHTPPYA ACLGFEFRKH LGNPAKDGGN VTVSLFYRND SAHLPLPLSL PGCPAPCPLG
   361  RFYQLTAPAR PPAHGVSCHG PYEAAIPPAP VVPLLAGAVA VLVALSLGLG LLAWRPGCLR
   421  ALGGPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

3.5 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACP4.

Disease | AllUniProt

Conditions ACP4 is implicated in, by any mechanism.

• Amelogenesis imperfecta 1J (AI1J) MIM:617297

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 134 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Amelogenesis imperfecta, type 1J

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.51

gnomAD pLI

0

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of neuron projection development
• negative regulation of protein processing
• odontogenesis
• regulation of neuronal synaptic plasticity
• negative regulation of ERBB4 signaling pathway
• peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

Molecular functions

• acid phosphatase activity
• protein tyrosine phosphatase activity
• receptor tyrosine kinase binding

Cellular components

• glutamatergic synapse
• lysosome
• postsynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• Histidine phosphatase superfamily, clade-2
• Histidine phosphatase superfamily
• Histidine acid phosphatase active site
• Histidine Acid Phosphatase
• Histidine phosphatase superfamily (branch 2)

KeywordsUniProt

• Amelogenesis imperfecta
• Disulfide bond
• Glycoprotein
• Hydrolase
• Membrane
• Signal
• Transmembrane
• Transmembrane helix