Antp homeobox family, Deformed subfamily
IPR050609
Definition
The Antp homeobox family, specifically the Deformed subfamily, consists of sequence-specific transcription factors that are integral to a developmental regulatory system. These proteins confer specific positional identities to cells along the anterior-posterior axis during development. Members of the family are characterized by their ability to bind DNA at specific sites, influencing the transcription of genes involved in establishing body plans and segmental identities. The family plays a crucial role in the development of various species, from invertebrates to vertebrates, indicating a highly conserved function across different phyla. The proteins typically contain a homeobox domain that facilitates DNA binding, and some members have been shown to activate transcription of apoptotic activators or regulate gene expression related to cell fate specification and organ development.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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