Seroatlas · Human Serome Atlas

HOXC5

Homeobox protein Hox-C5

Also known as: HOX3, HOX3D, HXC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00444
Gene: HOXC5
Ensembl: ENSG00000172789
Chromosome: 12
Canonical length: 222 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q00444|HOXC5
     1  MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG
    61  VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE
   121  EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETDGKRSRT SYTRYQTLEL EKEFHFNRYL
   181  TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKMKSKE AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 5.5 nTPM
stomach: 3 nTPM
epididymis: 2.6 nTPM
ovary: 2.5 nTPM
spinal cord: 1.9 nTPM
testis: 1.5 nTPM

Single-cell type

lymphatic endothelial cells: 0.3 nCPM
epididymal basal cells: 0.2 nCPM
epididymal efferent duct absorptive cells: 0.1 nCPM
epididymal principal cells: 0.1 nCPM
fallopian secretory cells: 0.1 nCPM
fallopian tube ciliated cells: 0.1 nCPM

Immune cell

gdT-cell: 3 nTPM
naive CD8 T-cell: 0.8 nTPM
memory CD8 T-cell: 0.4 nTPM
total PBMC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

pons: 7.6 nTPM
medulla oblongata: 5.9 nTPM
spinal cord: 4.2 nTPM
white matter: 2.5 nTPM
midbrain: 0.3 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -0.58
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXC5 as an antibody target. Whether an autoantibody or antibody against HOXC5 could matter depends on whether native HOXC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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