Seroatlas · Human Serome Atlas

HOXB4

Homeobox protein Hox-B4

Also known as: HOX2, HOX2F, HXB4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17483
Gene: HOXB4
Ensembl: ENSG00000182742
Chromosome: 17
Canonical length: 251 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>P17483|HOXB4
     1  MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC
    61  TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG ALLPEPGQRC EAVSSSPPPP
   121  PCAQNPLHPS PSHSACKEPV VYPWMRKVHV STVNPNYAGG EPKRSRTAYT RQQVLELEKE
   181  FHYNRYLTRR RRVEIAHALC LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP
   241  PGRPNGGPRA L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

epididymis: 19 nTPM
colon: 15 nTPM
fallopian tube: 13 nTPM
kidney: 12 nTPM
adipose tissue: 9.1 nTPM
blood vessel: 7.5 nTPM

Single-cell type

epididymal efferent duct absorptive cells: 1.2 nCPM
fallopian tube ciliated cells: 1.2 nCPM
fallopian secretory cells: 1 nCPM
epididymal basal cells: 0.9 nCPM
epididymal efferent duct ciliated cells: 0.8 nCPM
differentiating spermatogonia: 0.7 nCPM

Immune cell

plasmacytoid DC: 0.7 nTPM
gdT-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 25 nTPM
spinal cord: 19 nTPM
white matter: 12 nTPM
pons: 9.5 nTPM
thalamus: 0.5 nTPM
midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.06
gnomAD missense Z: 0.55
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXB4 as an antibody target. Whether an autoantibody or antibody against HOXB4 could matter depends on whether native HOXB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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