Seroatlas · Human Serome Atlas

HOXA4

Homeobox protein Hox-A4

Also known as: HOX1, HOX1D, HXA4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00056
Gene: HOXA4
Ensembl: ENSG00000197576
Chromosome: 7
Canonical length: 320 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies

OverviewNCBI Gene

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q00056|HOXA4
     1  MTMSSFLINS NYIEPKFPPF EEYAQHSGSG GADGGPGGGP GYQQPPAPPT QHLPLQQPQL
    61  PHAGGGREPT ASYYAPRTAR EPAYPAAALY PAHGAADTAY PYGYRGGASP GRPPQPEQPP
   121  AQAKGPAHGL HASHVLQPQL PPPLQPRAVP PAAPRRCEAA PATPGVPAGG SAPACPLLLA
   181  DKSPLGLKGK EPVVYPWMKK IHVSAVNPSY NGGEPKRSRT AYTRQQVLEL EKEFHFNRYL
   241  TRRRRIEIAH TLCLSERQVK IWFQNRRMKW KKDHKLPNTK MRSSNSASAS AGPPGKAQTQ
   301  SPHLHPHPHP STSTPVPSSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 36 nTPM
fallopian tube: 27 nTPM
parathyroid gland: 24 nTPM
kidney: 19 nTPM
skeletal muscle: 18 nTPM
adipose tissue: 16 nTPM

Single-cell type

endometrial secretory cells: 1 nCPM
epididymal efferent duct absorptive cells: 0.3 nCPM
mesothelial cells: 0.3 nCPM
breast lactating cells: 0.2 nCPM
smooth muscle cells: 0.2 nCPM
breast secretory cells: 0.1 nCPM

Immune cell

memory B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 42 nTPM
pons: 35 nTPM
spinal cord: 33 nTPM
white matter: 30 nTPM
midbrain: 1.8 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: 0.19
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXA4 as an antibody target. Whether an autoantibody or antibody against HOXA4 could matter depends on whether native HOXA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXA4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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