Seroatlas · Human Serome Atlas

DYRK4

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Also known as: DYRK4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NR20
Gene
DYRK4
Ensembl
ENSG00000010219
Chromosome
12
Canonical length
520 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q9NR20|DYRK4
     1  MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY
    61  AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK
   121  CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC
   181  ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ
   241  KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG
   301  YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK
   361  DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS
   421  FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP
   481  QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYRK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • testis: 34 nTPM
  • epididymis: 16 nTPM
  • thyroid gland: 8.5 nTPM
  • retina: 7.1 nTPM
  • seminal vesicle: 6.7 nTPM
  • placenta: 6.4 nTPM

Single-cell type

  • late spermatids: 447 nCPM
  • early spermatids: 339 nCPM
  • late primary spermatocytes: 50 nCPM
  • oocytes: 23 nCPM
  • undifferentiated spermatogonia: 17 nCPM
  • gastric chief cells: 16 nCPM

Immune cell

  • memory B-cell: 4.5 nTPM
  • non-classical monocyte: 3.5 nTPM
  • naive B-cell: 3 nTPM
  • classical monocyte: 1.7 nTPM
  • myeloid DC: 1.6 nTPM
  • intermediate monocyte: 1.3 nTPM

Brain region

  • white matter: 7.9 nTPM
  • cerebellum: 6.8 nTPM
  • thalamus: 6.5 nTPM
  • medulla oblongata: 6.2 nTPM
  • cerebral cortex: 5.9 nTPM
  • pons: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.51
gnomAD pLI
0
gnomAD missense Z
-0.25
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYRK4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYRK4 as an antibody target. Whether an autoantibody or antibody against DYRK4 could matter depends on whether native DYRK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYRK4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYRK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DYRK4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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