Seroatlas · Human Serome Atlas

DYRK2

Dual specificity tyrosine-phosphorylation-regulated kinase 2

Also known as: DYRK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92630
Gene: DYRK2
Ensembl: ENSG00000127334
Chromosome: 12
Canonical length: 601 aa
Protein class: Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

601 residues, UniProt reviewed canonical sequence.

>Q92630|DYRK2
     1  MLTRKPSAAA PAAYPTGRGG DSAVRQLQAS PGLGAGATRS GVGTGPPSPI ALPPLRASNA
    61  AAAAHTIGGS KHTMNDHLHV GSHAHGQIQV QQLFEDNSNK RTVLTTQPNG LTTVGKTGLP
   121  VVPERQLDSI HRRQGSSTSL KSMEGMGKVK ATPMTPEQAM KQYMQKLTAF EHHEIFSYPE
   181  IYFLGLNAKK RQGMTGGPNN GGYDDDQGSY VQVPHDHVAY RYEVLKVIGK GSFGQVVKAY
   241  DHKVHQHVAL KMVRNEKRFH RQAAEEIRIL EHLRKQDKDN TMNVIHMLEN FTFRNHICMT
   301  FELLSMNLYE LIKKNKFQGF SLPLVRKFAH SILQCLDALH KNRIIHCDLK PENILLKQQG
   361  RSGIKVIDFG SSCYEHQRVY TYIQSRFYRA PEVILGARYG MPIDMWSLGC ILAELLTGYP
   421  LLPGEDEGDQ LACMIELLGM PSQKLLDASK RAKNFVSSKG YPRYCTVTTL SDGSVVLNGG
   481  RSRRGKLRGP PESREWGNAL KGCDDPLFLD FLKQCLEWDP AVRMTPGQAL RHPWLRRRLP
   541  KPPTGEKTSV KRITESTGAI TSISKLPPPS SSASKLRTNL AQMTDANGNI QQRTVLPKLV
   601  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYRK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 37 nTPM
small intestine: 26 nTPM
colon: 24 nTPM
heart muscle: 23 nTPM
thymus: 22 nTPM
rectum: 21 nTPM

Single-cell type

colonocytes: 87 nCPM
goblet cells: 81 nCPM
myonuclei: 69 nCPM
enterocytes: 65 nCPM
retinal horizontal cells: 56 nCPM
myosatellite cells: 50 nCPM

Immune cell

NK-cell: 4.7 nTPM
memory CD8 T-cell: 4.2 nTPM
eosinophil: 4 nTPM
naive CD8 T-cell: 3.7 nTPM
gdT-cell: 3.2 nTPM
MAIT T-cell: 2.3 nTPM

Brain region

hippocampal formation: 27 nTPM
cerebral cortex: 22 nTPM
medulla oblongata: 17 nTPM
white matter: 17 nTPM
basal ganglia: 16 nTPM
spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 1.95
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYRK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYRK2 as an antibody target. Whether an autoantibody or antibody against DYRK2 could matter depends on whether native DYRK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYRK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYRK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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