Seroatlas · Human Serome Atlas

DYRK3

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Also known as: DYRK3_HUMAN, hYAK3-2, RED, REDK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43781
Gene: DYRK3
Ensembl: ENSG00000143479
Chromosome: 1
Canonical length: 588 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>O43781|DYRK3
     1  MGGTARGPGR KDAGPPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPPPR
    61  RLNMTTEQFT GDHTQHFLDG GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS
   121  SDCLNTVKSN SSSKAPKVVP LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG
   181  VIGGPNNGGY DDADGAYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV
   241  RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK
   301  KNKFQGFSVQ LVRKFAQSIL QSLDALHKNK IIHCDLKPEN ILLKHHGRSS TKVIDFGSSC
   361  FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC
   421  MMELLGMPPP KLLEQSKRAK YFINSKGIPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS
   481  KDWGTALKGC DDYLFIEFLK RCLHWDPSAR LTPAQALRHP WISKSVPRPL TTIDKVSGKR
   541  VVNPASAFQG LGSKLPPVVG IANKLKANLM SETNGSIPLC SVLPKLIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYRK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

testis: 45 nTPM
gallbladder: 13 nTPM
bone marrow: 8.3 nTPM
choroid plexus: 7.8 nTPM
heart muscle: 7.8 nTPM
thyroid gland: 7.8 nTPM

Single-cell type

late primary spermatocytes: 365 nCPM
early spermatids: 214 nCPM
erythrocyte progenitors: 91 nCPM
salivary basal cells: 90 nCPM
salivary myoepithelial cells: 73 nCPM
alveolar cells type 2: 70 nCPM

Immune cell

plasmacytoid DC: 2.7 nTPM
basophil: 0.7 nTPM
neutrophil: 0.5 nTPM
eosinophil: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM

Brain region

choroid plexus: 12 nTPM
hippocampal formation: 11 nTPM
midbrain: 11 nTPM
medulla oblongata: 8.3 nTPM
hypothalamus: 8.2 nTPM
basal ganglia: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYRK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SIRT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYRK3 as an antibody target. Whether an autoantibody or antibody against DYRK3 could matter depends on whether native DYRK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYRK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYRK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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