Fibrinogen C-terminal domain-containing protein
IPR050373
Definition
This family of proteins includes members with diverse roles in innate immunity, angiogenesis, metabolism, and cell adhesion. They are characterized by the presence of a fibrinogen C-terminal domain, which is implicated in various interactions such as binding to carbohydrates, cell surface receptors, or acetylated structures. Some family members function as lectins that recognize specific carbohydrate moieties, initiating complement activation or modulating cell adhesion. Others are involved in vascular development and stability, competing for receptor binding sites and influencing signaling pathways that regulate endothelial cell survival, proliferation, and migration. Additionally, certain proteins within this family can impact lipid metabolism by modulating the activity of enzymes like lipoprotein lipase, influencing triglyceride and cholesterol levels.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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