Seroatlas · Human Serome Atlas

MFAP4

Microfibril-associated glycoprotein 4

Also known as: MFAP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55083
Gene
MFAP4
Ensembl
ENSG00000166482
Chromosome
17
Canonical length
255 aa
Protein class
Plasma proteins, Predicted secreted proteins
Subcellular location
Endoplasmic reticulum
Secretome location
Secreted to extracellular matrix
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>P55083|MFAP4
     1  MKALLALPLL LLLSTPPCAP QVSGIRGDAL ERFCLQQPLD CDDIYAQGYQ SDGVYLIYPS
    61  GPSVPVPVFC DMTTEGGKWT VFQKRFNGSV SFFRGWNDYK LGFGRADGEY WLGLQNMHLL
   121  TLKQKYELRV DLEDFENNTA YAKYADFSIS PNAVSAEEDG YTLFVAGFED GGAGDSLSYH
   181  SGQKFSTFDR DQDLFVQNCA ALSSGAFWFR SCHFANLNGF YLGGSHLSYA NGINWAQWKG
   241  FYYSLKRTEM KIRRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFAP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
1,056 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 1,056 nTPM
  • lung: 627 nTPM
  • gallbladder: 606 nTPM
  • urinary bladder: 457 nTPM
  • colon: 283 nTPM
  • esophagus: 276 nTPM

Single-cell type

  • fibroblasts: 590 nCPM
  • decidual stromal cells: 310 nCPM
  • smooth muscle cells: 239 nCPM
  • hepatic stellate cells: 226 nCPM
  • peritubular myoid cells: 207 nCPM
  • vascular smooth muscle cells: 165 nCPM

Immune cell

  • non-classical monocyte: 1.9 nTPM
  • intermediate monocyte: 1.8 nTPM
  • eosinophil: 1 nTPM
  • classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 20 nTPM
  • basal ganglia: 13 nTPM
  • midbrain: 12 nTPM
  • hypothalamus: 10 nTPM
  • cerebral cortex: 9.6 nTPM
  • thalamus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.11
gnomAD missense Z
1.35
DepMap mean gene effect
-0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MFAP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFAP4 as an antibody target. Whether an autoantibody or antibody against MFAP4 could matter depends on whether native MFAP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFAP4 is annotated as secreted, so native MFAP4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MFAP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MFAP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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