Seroatlas · Human Serome Atlas

FGL2

Fibroleukin

Also known as: FGL2_HUMAN, pT49, T49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14314
Gene
FGL2
Ensembl
ENSG00000127951
Chromosome
7
Canonical length
439 aa
Protein class
Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q14314|FGL2
     1  MKLANWYWLS SAVLATYGFL VVANNETEEI KDERAKDVCP VRLESRGKCE EAGECPYQVS
    61  LPPLTIQLPK QFSRIEEVFK EVQNLKEIVN SLKKSCQDCK LQADDNGDPG RNGLLLPSTG
   121  APGEVGDNRV RELESEVNKL SSELKNAKEE INVLHGRLEK LNLVNMNNIE NYVDSKVANL
   181  TFVVNSLDGK CSKCPSQEQI QSRPVQHLIY KDCSDYYAIG KRSSETYRVT PDPKNSSFEV
   241  YCDMETMGGG WTVLQARLDG STNFTRTWQD YKAGFGNLRR EFWLGNDKIH LLTKSKEMIL
   301  RIDLEDFNGV ELYALYDQFY VANEFLKYRL HVGNYNGTAG DALRFNKHYN HDLKFFTTPD
   361  KDNDRYPSGN CGLYYSSGWW FDACLSANLN GKYYHQKYRG VRNGIFWGTW PGVSEAHPGG
   421  YKSSFKEAKM MIRPKHFKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
154 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 154 nTPM
  • spleen: 153 nTPM
  • appendix: 84 nTPM
  • urinary bladder: 69 nTPM
  • small intestine: 66 nTPM
  • rectum: 54 nTPM

Single-cell type

  • schwann cells: 614 nCPM
  • kupffer cells: 591 nCPM
  • monocytes: 590 nCPM
  • cdc: 536 nCPM
  • macrophages: 448 nCPM
  • monocyte progenitors: 140 nCPM

Immune cell

  • non-classical monocyte: 382 nTPM
  • intermediate monocyte: 380 nTPM
  • neutrophil: 295 nTPM
  • classical monocyte: 256 nTPM
  • eosinophil: 227 nTPM
  • total PBMC: 174 nTPM

Brain region

  • white matter: 21 nTPM
  • medulla oblongata: 17 nTPM
  • midbrain: 13 nTPM
  • spinal cord: 13 nTPM
  • choroid plexus: 13 nTPM
  • hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGL2 as an antibody target. Whether an autoantibody or antibody against FGL2 could matter depends on whether native FGL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGL2 is annotated as secreted, so native FGL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...