Seroatlas · Human Serome Atlas

FIBCD1

Fibrinogen C domain-containing protein 1

Also known as: FBCD1_HUMAN, FLJ14810

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N539
Gene: FIBCD1
Ensembl: ENSG00000130720
Chromosome: 9
Canonical length: 461 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions
Quaternary structure: Homotetramer

OverviewNCBI Gene

FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q8N539|FIBCD1
     1  MVNDRWKTMG GAAQLEDRPR DKPQRPSCGY VLCTVLLALA VLLAVAVTGA VLFLNHAHAP
    61  GTAPPPVVST GAASANSALV TVERADSSHL SILIDPRCPD LTDSFARLES AQASVLQALT
   121  EHQAQPRLVG DQEQELLDTL ADQLPRLLAR ASELQTECMG LRKGHGTLGQ GLSALQSEQG
   181  RLIQLLSESQ GHMAHLVNSV SDILDALQRD RGLGRPRNKA DLQRAPARGT RPRGCATGSR
   241  PRDCLDVLLS GQQDDGVYSV FPTHYPAGFQ VYCDMRTDGG GWTVFQRRED GSVNFFRGWD
   301  AYRDGFGRLT GEHWLGLKRI HALTTQAAYE LHVDLEDFEN GTAYARYGSF GVGLFSVDPE
   361  EDGYPLTVAD YSGTAGDSLL KHSGMRFTTK DRDSDHSENN CAAFYRGAWW YRNCHTSNLN
   421  GQYLRGAHAS YADGVEWSSW TGWQYSLKFS EMKIRPVRED R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FIBCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 24 nTPM
parathyroid gland: 12 nTPM
adrenal gland: 9.9 nTPM
testis: 6.4 nTPM
lung: 2 nTPM
amygdala: 1.5 nTPM

Single-cell type

late spermatids: 66 nCPM
retinal amacrine cells: 30 nCPM
late primary spermatocytes: 26 nCPM
early spermatids: 18 nCPM
differentiating spermatogonia: 18 nCPM
goblet cells: 16 nCPM

Immune cell

non-classical monocyte: 1.1 nTPM
intermediate monocyte: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hippocampal formation: 60 nTPM
cerebral cortex: 35 nTPM
medulla oblongata: 20 nTPM
amygdala: 18 nTPM
midbrain: 14 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FIBCD1 as an antibody target. Whether an autoantibody or antibody against FIBCD1 could matter depends on whether native FIBCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FIBCD1 is annotated as secreted, so native FIBCD1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FIBCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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