Seroatlas · Human Serome Atlas

ANGPTL5

Angiopoietin-related protein 5

Also known as: ANGL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XS5
Gene: ANGPTL5
Ensembl: ENSG00000187151
Chromosome: 11
Canonical length: 388 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q86XS5|ANGPTL5
     1  MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES KSNDTVCKED
    61  CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN MMDEQQASLD YLSNQVNELM
   121  NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC TDIKDTIGSV TKTPSGLYII HPEGSSYPFE
   181  VMCDMDYRGG GRTVIQKRID GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS
   241  FMLYVALESE DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF
   301  STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS GKLLATGIQW
   361  GTWTKNNSPV KIKSVSMKIR RMYNPYFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANGPTL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

ovary: 19 nTPM
breast: 5.2 nTPM
epididymis: 4.1 nTPM
adipose tissue: 4 nTPM
heart muscle: 2.6 nTPM
skin: 2.3 nTPM

Single-cell type

ovarian stromal cells: 69 nCPM
fibroblasts: 33 nCPM
epicardial cells: 30 nCPM
leydig cells: 28 nCPM
peritubular myoid cells: 16 nCPM
decidual stromal cells: 15 nCPM

Immune cell

NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 0.9 nTPM
cerebellum: 0.6 nTPM
hypothalamus: 0.6 nTPM
basal ganglia: 0.5 nTPM
cerebral cortex: 0.5 nTPM
medulla oblongata: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANGPTL5 as an antibody target. Whether an autoantibody or antibody against ANGPTL5 could matter depends on whether native ANGPTL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANGPTL5 is annotated as secreted, so native ANGPTL5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ANGPTL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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